Association Between a Dopamine-4 Receptor Polymorphism and Blood Pressure | Zendy

Srijan Sen | Zendy; Randolph M. Nesse | Zendy; Liang Sheng | Zendy; Scott F. Stoltenberg | Zendy; Lillian Gleiberman | Zendy; Margit Burmeister | Zendy; A Weder | Zendy

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Association Between a Dopamine-4 Receptor Polymorphism and Blood Pressure

Author(s) -

Srijan Sen,

Randolph M. Nesse,

Liang Sheng,

Scott F. Stoltenberg,

Lillian Gleiberman,

Margit Burmeister,

A Weder

Publication year - 2005

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.04.010

Subject(s) - endocrinology , medicine , blood pressure , dopamine , dopamine receptor d3 , allele , dopamine receptor , novelty seeking , polymorphism (computer science) , receptor , genetics , biology , gene , psychology , personality , big five personality traits , social psychology

Dopamine receptor genes are candidates for hypertension susceptibility. Locally released dopamine increases renal sodium excretion, and defective renal dopamine receptor signaling has been shown to play a role in hypertension. Dopamine-4 receptors are expressed in juxtaglomerular and cortical collecting cells, where dopamine activation could alter sodium and water metabolism and affect blood pressure (BP). The dopamine-4 receptor (DRD4) gene has a 16 amino acid (48 base pairs [bp]) repeat polymorphism located in exon 3 where a G-protein binding area is encoded. The long allele (defined as at least one 7 to 10 repeat) has been associated with the personality trait Novelty Seeking and with substance abuse, but associations between dopamine-4 receptor polymorphisms and BP have not been reported.

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