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Increase of Serum Angiopoietin-2 During Pregnancy Is Suppressed in Women With Preeclampsia
Author(s) -
Kumiko Hirokoshi,
Yohei Maeshima,
Kunihiko Kobayashi,
Eiji Matsuura,
Hitoshi Sugiyama,
Yasuhiro Yamasaki,
Hisashi Masuyama,
Y Hiramatsu,
Hirofumi Makino
Publication year - 2005
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1016/j.amjhyper.2005.03.745
Subject(s) - angiopoietin 2 , preeclampsia , medicine , angiogenesis , angiopoietin , vascular endothelial growth factor , angiopoietin receptor , pregnancy , endocrinology , placental growth factor , vegf receptors , biology , genetics
Numerous recent reports demonstrated that changes in serum levels of angiogenesis-related factors were associated with preeclampsia. Here, we determined the serum concentration of angiopoietin-2 (Ang-2), a natural antagonist of angiopoietin-1 (Ang-1) involved in promoting angiogenesis in the presence of angiogenic stimuli such as vascular endothelial growth factor (VEGF), in women with preeclampsia.

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