Preservation of the arterial pressure response to leptin in diet-induced obese mice: A potential mechanism for obesity hypertension | Zendy

Kamal Rahmouni | Zendy; Gareth Morgan | Zendy; Donald A. Morgan | Zendy; A MARK | Zendy; William G. Haynes | Zendy

Open Access

Preservation of the arterial pressure response to leptin in diet-induced obese mice: A potential mechanism for obesity hypertension

Author(s) -

Kamal Rahmouni,

Gareth Morgan,

Donald A. Morgan,

A MARK,

William G. Haynes

Publication year - 2005

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.03.556

Subject(s) - leptin , medicine , endocrinology , mean arterial pressure , blood pressure , obesity , diet induced obese , heart rate , insulin resistance

by 34.62% (P 0.05) vs the control. IRI and C-peptid initial levels in group III increased by about 4 times compared to group I and the control (P 0.05). These factors decreased 25.81% (P 0.05) and 52.68% (P 0.05) compared to the initial values and the control. The concentration of VEGF in group I was twice as high as in the control at 29.80 4.73 ng/ml vs 19.33 2.09 ng/ml in the control (P 0.05). E-1 levels for group I did not change at 2.63 0.95 pg/ml vs 1.50 0.15 pg/ml in the control (P 0.05). VEGF level decreased to that of the control (P 0.05) and E-1 level remained at that value. VEGF levels in groups II and III appeared to be 1.5-2 times higher than the control. VEGF after treatment decreased but was still higher than the control by 22.65% (P 0.05). The E-1 blood levels in groups II and III were higher by a factor of 5 and 7 times (P 0.05) vs the control. E-1 levels decreased by a factor of 2-3, but did not reach the control. In conclusion, moxonidine decreased the level of hyperinsulinemia, normalized the insulin secretion and endothelial vasoregulation in patients with AH and IR.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research