Analysis of the 11β-Hydroxysteroid Dehydrogenase Type 2 Gene (HSD11B2) in Human Essential Hypertension | Zendy

Barbara Mariniello | Zendy; Vanessa Ronconi | Zendy; C Sardu | Zendy; A PAGLIERICCIO | Zendy; Ferruccio Galletti | Zendy; Pasquale Strazzullo | Zendy; M. Palermo | Zendy; Marco Boscaro | Zendy; Paul M. Stewart | Zendy; Franco Mantero | Zendy

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Analysis of the 11β-Hydroxysteroid Dehydrogenase Type 2 Gene (HSD11B2) in Human Essential Hypertension

Author(s) -

Barbara Mariniello,

Vanessa Ronconi,

C Sardu,

A PAGLIERICCIO,

Ferruccio Galletti,

Pasquale Strazzullo,

M. Palermo,

Marco Boscaro,

Paul M. Stewart,

Franco Mantero

Publication year - 2005

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.02.020

Subject(s) - medicine , essential hypertension , exon , genotype , polymorphism (computer science) , endocrinology , gene , polymerase chain reaction , allele , urinary system , genetics , blood pressure , biology

The HSD11B2 gene, encoding the kidney isoenzyme 11beta-hydroxysteroid dehydrogenase, is a candidate for essential hypertension. We previously showed that the frequency of shorter alleles of a CA repeat polymorphism in the first intron of 11beta-HSD2 gene was significantly higher among salt-sensitive than salt-resistant individuals with hypertension. The aim of the study was to analyze the HSD11B2 gene to assess whether some of its variants might be involved in hypertension.

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