Demographic, Environmental, and Genetic Predictors of Metabolic Side Effects of Hydrochlorothiazide Treatment in Hypertensive Subjects | Zendy

Anke H. Maitlandvan der Zee | Zendy; Stephen T. Turner | Zendy; G SCHWARTZ | Zendy; A CHAPMAN | Zendy; Olaf H. Klungel | Zendy; E BOERWINKLE | Zendy

Open Access

Demographic, Environmental, and Genetic Predictors of Metabolic Side Effects of Hydrochlorothiazide Treatment in Hypertensive Subjects

Author(s) -

Anke H. Maitlandvan der Zee,

Stephen T. Turner,

G SCHWARTZ,

A CHAPMAN,

Olaf H. Klungel,

E BOERWINKLE

Publication year - 2005

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.02.012

Subject(s) - hydrochlorothiazide , medicine , dyslipidemia , endocrinology , thiazide , triglyceride , diabetes mellitus , blood pressure , metabolic syndrome , pharmacogenetics , body mass index , genetic variation , cholesterol , population , genotype , biology , genetics , environmental health , gene

Thiazide diuretics are recommended for first-line treatment of hypertension. Although considered safe and effective, their use is associated with dyslipidemia, hyperglycemia, and an increased risk of developing type 2 diabetes. The aim of this study was to characterize interindividual variation in glucose and lipid responses to hydrochlorothiazide and to identify demographic, environmental, and genetic predictors associated with this variation.

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