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High-density lipoprotein (HDL)-cholesterol, triglycerides, and LDL particle size are correlated lipid traits. Abnormal levels of these traits are frequent in hypertensive individuals and contribute to increased risk of coronary heart disease (CHD). We performed univariate and bivariate linkage analyses to identify genomic regions that influence levels of these traits and exert pleiotropic effects on the traits in hypertensive sibships.

A Novel Quantitative Trait Locus on Chromosome 1 with Pleiotropic Effects on HDL-Cholesterol and LDL Particle Size in Hypertensive Sibships