A Novel Quantitative Trait Locus on Chromosome 1 with Pleiotropic Effects on HDL-Cholesterol and LDL Particle Size in Hypertensive Sibships | Zendy

Iftikhar J. Kullo | Zendy; S. T. Turner | Zendy; E BOERWINKLE | Zendy; Sharon L.R. Kardia | Zendy; Mariza deAndrade | Zendy

Open Access

A Novel Quantitative Trait Locus on Chromosome 1 with Pleiotropic Effects on HDL-Cholesterol and LDL Particle Size in Hypertensive Sibships

Author(s) -

Iftikhar J. Kullo,

S. T. Turner,

E BOERWINKLE,

Sharon L.R. Kardia,

Mariza deAndrade

Publication year - 2005

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.02.010

Subject(s) - quantitative trait locus , genetics , genetic linkage , locus (genetics) , medicine , cholesterol , biology , endocrinology , gene

High-density lipoprotein (HDL)-cholesterol, triglycerides, and LDL particle size are correlated lipid traits. Abnormal levels of these traits are frequent in hypertensive individuals and contribute to increased risk of coronary heart disease (CHD). We performed univariate and bivariate linkage analyses to identify genomic regions that influence levels of these traits and exert pleiotropic effects on the traits in hypertensive sibships.

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