Adrenal Angiotensin: Origin and Site of Generation | Zendy

Jorge P vanKats | Zendy; Wangjing Chai | Zendy; D DUNCKER | Zendy; Maarten A.D.H. Schalekamp | Zendy; AH Jan Danser | Zendy

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Adrenal Angiotensin: Origin and Site of Generation

Author(s) -

Jorge P vanKats,

Wangjing Chai,

D DUNCKER,

Maarten A.D.H. Schalekamp,

AH Jan Danser

Publication year - 2005

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.02.005

Subject(s) - medicine , angiotensin ii , renin–angiotensin system , endocrinology , cardiology , blood pressure

Circulating angiotensin (Ang) II accumulates in adrenal tissue via binding to Ang II type 1 (AT1) receptors, reaching levels that are 15 to 20 times higher than in blood. Adrenal tissue contains a second renin transcript that gives rise to a truncated prorenin representing a cytosolic form of renin. Here we investigated what percentage of adrenal Ang II originates at adrenal tissue sites, and whether intracellular renin contributes to adrenal angiotensin production.

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