β-Adrenoceptor Polymorphisms Relate to Insulin Resistance and Sympathetic Overactivity as Early Markers of Metabolic Disease in Nonobese, Normotensive Individuals | Zendy

Kazuko Masuo | Zendy; Tomohiro Katsuya | Zendy; Yuan Fu | Zendy; Hiromi Rakugi | Zendy; Takehide Ogihara | Zendy; Matthew Tuck | Zendy

Open Access

β-Adrenoceptor Polymorphisms Relate to Insulin Resistance and Sympathetic Overactivity as Early Markers of Metabolic Disease in Nonobese, Normotensive Individuals

Author(s) -

Kazuko Masuo,

Tomohiro Katsuya,

Yuan Fu,

Hiromi Rakugi,

Takehide Ogihara,

Matthew Tuck

Publication year - 2005

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2005.01.006

Subject(s) - insulin resistance , medicine , endocrinology , insulin , obesity , insulin receptor , body mass index , leptin , diabetes mellitus , blood pressure , hyperinsulinemia , allele , biology , gene , genetics

The genes responsible for insulin resistance are also candidate genes for insulin resistance-related diseases, such as obesity and hypertension. Functional polymorphisms in the beta2- and beta3-adrenergic receptors have been reported to be associated with diabetes, hypertension, and obesity. To clarify the relevance of the beta-adrenergic receptor polymorphisms to insulin resistance, we studied their association with polymorphisms of beta2 (Arg16Gly, Gln27Glu) and beta3 (Trp64Arg) adrenoceptor genes.

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