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The genes responsible for insulin resistance are also candidate genes for insulin resistance-related diseases, such as obesity and hypertension. Functional polymorphisms in the beta2- and beta3-adrenergic receptors have been reported to be associated with diabetes, hypertension, and obesity. To clarify the relevance of the beta-adrenergic receptor polymorphisms to insulin resistance, we studied their association with polymorphisms of beta2 (Arg16Gly, Gln27Glu) and beta3 (Trp64Arg) adrenoceptor genes.

american journal of hypertension

β-Adrenoceptor Polymorphisms Relate to Insulin Resistance and Sympathetic Overactivity as Early Markers of Metabolic Disease in Nonobese, Normotensive Individuals