Natriuretic Response to Direct Renal Interstitial Volume Expansion (DRIVE) in Pregnant Rats | Zendy

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Natriuretic Response to Direct Renal Interstitial Volume Expansion (DRIVE) in Pregnant Rats

Author(s) -

T YU,

AA Khraibi

Publication year - 2005

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2004.12.019

Subject(s) - natriuresis , endocrinology , medicine , fractional excretion of sodium , diuretic , diuresis , excretion , hydrostatic pressure , urine flow rate , kidney , physics , thermodynamics

Basal renal interstitial hydrostatic pressure (RIHP) is lower in pregnant rats, suggesting an increase in renal interstitial compliance during pregnancy. The RIHP responses to increases in renal perfusion pressure (RPP) and acute saline volume expansion (VE) are attenuated in pregnant rats. Pressure natriuresis and diuresis responses are significantly attenuated during normal pregnancy, whereas the natriuretic and diuretic responses to VE remain intact.

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