Open AccessTempol Attenuates the Development of Hypertensive Renal Injury in Dahl Salt-Sensitive Rats
Author(s) -
Ryouhei HISAKI,
Hideki Fujita,
Fumio Saito,
Toshio Kushiro
Publication year - 2005
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1016/j.amjhyper.2004.11.045
Subject(s) - medicine , oxidative stress , endocrinology , nephrosclerosis , creatinine , hypertensive nephropathy , blood pressure , kidney , diabetic nephropathy
Dahl salt-sensitive (DS) rats given a high-salt diet develop renal lesions that are virtually identical to those in human hypertensive nephrosclerosis and are associated with increased oxidative stress. This study looks at the effects of a superoxide scavenger in preventing of hypertensive renal damage in high-salt-treated DS rats.
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