Association of C825T polymorphism of G protein ?3 subunit with the autonomic nervous system in young healthy Japanese individuals | Zendy

Tetsuro Matsunaga | Zendy; Kae Nagasumi | Zendy; Taku Yamamura | Zendy; Ning Gu | Zendy; Mariko Nishikino | Zendy; Yuki UEDA | Zendy; Toshio Moritani | Zendy; N AOKI | Zendy; K TSUDA | Zendy; Keishu Yasuda | Zendy

Open Access

Association of C825T polymorphism of G protein ?3 subunit with the autonomic nervous system in young healthy Japanese individuals

Author(s) -

Tetsuro Matsunaga,

Kae Nagasumi,

Taku Yamamura,

Ning Gu,

Mariko Nishikino,

Yuki UEDA,

Toshio Moritani,

N AOKI,

K TSUDA,

Keishu Yasuda

Publication year - 2005

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2004.11.008

Subject(s) - medicine , autonomic nervous system , endocrinology , genotype , body mass index , blood pressure , heart rate variability , allele , supine position , heart rate , genetics , biology , gene

The T allele of the C825T polymorphism of the G protein beta3 subunit gene (GNB3) is reported to be associated with increased intracellular signal transduction and the prevalence of essential hypertension. Because the two major receptors in the autonomic nervous system (ANS), the adrenergic and muscarinic acetylcholine receptors, are G protein-coupled receptors, it was expected that the GNB3 C825T polymorphism was associated with ANS function. In the present study, we have investigated the association of this polymorphism with ANS in young, healthy Japanese male individuals.

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