Association study of calcitonin-receptor-like receptor gene in essential hypertension | Zendy

Mary Sano | Zendy; Nobuhiro Kuroi | Zendy; Toshinori Nakayama | Zendy; Naoyuki Sato | Zendy; Yoko Izumi | Zendy; Masayoshi Soma | Zendy; Shinichiro Kokubun | Zendy

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Association study of calcitonin-receptor-like receptor gene in essential hypertension

Author(s) -

Mary Sano,

Nobuhiro Kuroi,

Toshinori Nakayama,

Naoyuki Sato,

Yoko Izumi,

Masayoshi Soma,

Shinichiro Kokubun

Publication year - 2005

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2004.10.016

Subject(s) - medicine , calcitonin receptor , receptor , calcitonin , endocrinology , calcitonin gene related peptide , gene , genetics , neuropeptide , biology

Plasma adrenomedullin (ADM) concentrations increase in patients with hypertension, renal failure, heart failure, essential pulmonary hypertension, myocardial infarction, endotoxin shock, and many other conditions. The ADM receptor is a complex molecule that consists of calcitonin-receptor-like receptor (CRLR) and receptor activity-modifying protein 2 (RAMP2). Because CRLR determines the binding specificity of ADM, the CRLR gene is thought to be a susceptibility gene of hypertension. However, studies have not yet defined the relationship between the CRLR gene and hypertension. The aim of the present study was to investigate relationships between single-nucleotide polymorphisms (SNP) in the human CRLR gene and essential hypertension (EH) in a Japanese population.

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