Inhibition of brain angiotensin-converting enzyme by peripheral administration of trandolapril versus lisinopril in Wistar rats | Zendy

Jinyun Tan | Zendy; Jun Wang | Zendy; F LEENEN | Zendy

Open Access

Inhibition of brain angiotensin-converting enzyme by peripheral administration of trandolapril versus lisinopril in Wistar rats

Author(s) -

Jinyun Tan,

Jun Wang,

F LEENEN

Publication year - 2005

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2004.09.004

Subject(s) - trandolapril , lisinopril , medicine , angiotensin converting enzyme , peripheral , renin–angiotensin system , pharmacology , endocrinology , ace inhibitor , blood pressure

Peripheral administration of blockers of the renin-angiotensin system (RAS) may affect the RAS in the brain to a variable degree. In the present study, we determined inhibition of angiotensin-converting enzyme (ACE) in the brain after peripheral administration of a lipophilic (trandolapril) versus hydrophilic (lisinopril) ACE inhibitor.

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