Short-Term oral folic acid supplementation enhances endothelial function in patients with type 2 diabetes
Author(s) -
Arduino A. Mangoni,
Roy Sherwood,
Belinda Asonganyi,
Cameron Swift,
Sarah Thomas,
Stephen R. Jackson
Publication year - 2005
Publication title -
american journal of hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1016/j.amjhyper.2004.08.036
Subject(s) - medicine , homocysteine , pulse wave velocity , endocrinology , type 2 diabetes , arterial stiffness , sodium nitroprusside , endothelium , endothelial dysfunction , diabetes mellitus , vasodilation , cardiology , blood pressure , nitric oxide
Endothelial dysfunction and arterial stiffening are commonly observed in type 2 diabetes. These abnormalities might be secondary to increased plasma concentrations of homocysteine. We sought to determine whether oral folic acid supplementation, by lowering homocysteine levels, enhanced endothelial function and reduced arterial stiffness in type 2 diabetes.
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