The effect of statins on angiotensin II-induced hemodynamic changes in young, mildly hypercholesterolemic men | Zendy

E. Fleischmann | Zendy; Stefan John | Zendy; Christian Delles | Zendy; Markus P. Schneider | Zendy; Boris Schmidt | Zendy; R. Schmieder | Zendy

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The effect of statins on angiotensin II-induced hemodynamic changes in young, mildly hypercholesterolemic men

Author(s) -

E. Fleischmann,

Stefan John,

Christian Delles,

Markus P. Schneider,

Boris Schmidt,

R. Schmieder

Publication year - 2004

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2004.07.011

Subject(s) - candesartan , medicine , angiotensin ii , angiotensin ii receptor type 1 , cerivastatin , hemodynamics , endocrinology , vascular resistance , blood pressure , cardiology , angiotensin receptor , cholesterol , pravastatin

Angiotensin II type 1 (AT(1)) receptors are well known to mediate angiotensin II (Ang II)-induced pro-atherosclerotic effects. It has been found that hypercholesterolemia influences the expression of AT(1) receptors on vascular smooth muscle cells and that increased density of AT(1) receptors exaggerates the hemodynamic response to Ang II. We analyzed to what extent statins and AT(1) receptor antagonists diminish the vasoconstrictive response to Ang II infusion in hypercholesterolemic patients.

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