Open AccessAn association study in essential hypertension using functional polymorphisms in lymphotoxin-? gene
Author(s) -
Toshinori Nakayama,
Masayoshi Soma,
Naoyuki Sato,
Akira Haketa,
K KOSUGE,
Noriaki Aoi,
Mikano Sato,
Yoko Izumi,
Ken Matsumoto,
Katsuo Kanmatsuse
Publication year - 2004
Publication title -
american journal of hypertension
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.009
H-Index - 136
eISSN - 1941-7225
pISSN - 0895-7061
DOI - 10.1016/j.amjhyper.2004.07.010
Subject(s) - single nucleotide polymorphism , haplotype , medicine , snp , lymphotoxin alpha , lymphotoxin , essential hypertension , candidate gene , genetic association , case control study , immunology , genotype , genetics , gene , tumor necrosis factor alpha , blood pressure , biology
Lymphotoxin-alpha (LTA), a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The substance LTA mediates a wide variety of inflammatory, immunostimulatory, and antiviral responses. In 2002, LTA was identified as a major risk factor for myocardial infarction (MI) in Japanese individuals, in a large-scale case-control study using 92,788 gene-based single-nucleotide polymorphism (SNP) markers in the whole human genome. Essential hypertension (EH) is thought to be a multifactorial disorder involved in endothelial dysfunction and atherosclerosis. Although hypertension is one of the greatest risk factors for MI, there have been no reports estimating the association between EH and LTA. The aim of the present study was to evaluate the association between EH and the LTA gene.
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