Lack of association between polymorphism in the ?-adrenergic receptor gene, hypertension, and obesity in the Olivetti Heart Study | Zendy

Ferruccio Galletti | Zendy; Roberto Iacone | Zendy; Eliana Ragone | Zendy; Ornella Russo | Zendy; Elisabetta Della Valle | Zendy; Alfonso Siani | Zendy; Gianvincenzo Barba | Zendy; Eduardo Farinaro | Zendy; Viviana Strazzullo | Zendy; Pasquale Strazzullo | Zendy

Open Access

Lack of association between polymorphism in the ?-adrenergic receptor gene, hypertension, and obesity in the Olivetti Heart Study

Author(s) -

Ferruccio Galletti,

Roberto Iacone,

Eliana Ragone,

Ornella Russo,

Elisabetta Della Valle,

Alfonso Siani,

Gianvincenzo Barba,

Eduardo Farinaro,

Viviana Strazzullo,

Pasquale Strazzullo

Publication year - 2004

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2004.04.012

Subject(s) - medicine , obesity , body mass index , overweight , genotype , endocrinology , blood pressure , polymorphism (computer science) , odds ratio , linkage disequilibrium , essential hypertension , genetics , haplotype , gene , biology

Several case-control studies have explored the possible association between polymorphism in the beta2 adrenoreceptor gene (beta2AR), hypertension, and obesity--the focus being in particular on the Arg16Gly and Gln27Glu substitutions, which appear to modify the extracellular part of the beta2AR with possible functional modification. However, controversial results have been obtained.

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