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Several case-control studies have explored the possible association between polymorphism in the beta2 adrenoreceptor gene (beta2AR), hypertension, and obesity--the focus being in particular on the Arg16Gly and Gln27Glu substitutions, which appear to modify the extracellular part of the beta2AR with possible functional modification. However, controversial results have been obtained.

Lack of association between polymorphism in the ?-adrenergic receptor gene, hypertension, and obesity in the Olivetti Heart Study