Roles of angiotensin type 1 and 2 receptors in pregnancy-associated blood pressure change*1 | Zendy

Yuko Takeda-Matsubara | Zendy; Masaru Iwai | Zendy; Taixing Cui | Zendy; Tetsuya Shiuchi | Zendy; Hongwei Liu | Zendy; Midori Okumura | Zendy; Masaharu Ito | Zendy; Masatsugu Horiuchi | Zendy

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Roles of angiotensin type 1 and 2 receptors in pregnancy-associated blood pressure change*1

Author(s) -

Yuko Takeda-Matsubara,

Masaru Iwai,

Taixing Cui,

Tetsuya Shiuchi,

Hongwei Liu,

Midori Okumura,

Masaharu Ito,

Masatsugu Horiuchi

Publication year - 2004

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2004.03.680

Subject(s) - endocrinology , medicine , angiotensin ii receptor type 1 , angiotensin ii , placenta , losartan , receptor , angiotensin receptor , vascular smooth muscle , renin–angiotensin system , vasoconstriction , pregnancy , blood pressure , biology , fetus , smooth muscle , genetics

Activation of the renin-angiotensin system with increased levels of renin and angiotensin (Ang) II in pregnancy has been reported, but the vascular responsiveness to Ang II seems to be decreased, thereby keeping maternal blood pressure (BP) constant. We postulated that the balance of angiotensin type 1 (AT1) and angiotensin type 2 (AT2) receptor expression, which would exert antagonistic actions on vasoconstriction and cell growth, might control BP in pregnancy.

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