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indicator Fura-2/AM. It was showed that endothelin and PDGF significantly induced a migration of vascular smooth muscle cells in a dosedependent manner, which was dose-dependently inhibited by pretreatment with 10-10mol/L sodium ferulate . The peak inhibition rate of migration induced by endothelin and PDGF were 85.04% and 81.92% (P 0.01) respectively. endothelin and PDGF provoked the rise of [Ca ]i in vascular smooth muscle cells, which was significantly suppressed by 10mol/L sodium ferulate (P 0.01). It is concluded that migration and rise of [Ca ]i induced by endothelin and PDGF in vascular smooth muscle cells from SHR may be suppressed by ferulate.

Effect of ferulate on attachment and migration induced by fibronectin and fibrinogen in cultured vascular smooth muscle cells from shr