Effect of ferulate on attachment and migration induced by fibronectin and fibrinogen in cultured vascular smooth muscle cells from shr | Zendy

Liangdi Xie | Zendy; Ying Han | Zendy; Huajun Wang | Zendy

Open Access

Effect of ferulate on attachment and migration induced by fibronectin and fibrinogen in cultured vascular smooth muscle cells from shr

Author(s) -

Liangdi Xie,

Ying Han,

Huajun Wang

Publication year - 2004

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2004.03.458

Subject(s) - fibronectin , vascular smooth muscle , fibrinogen , fura 2 , endocrinology , medicine , cell , cell migration , chemistry , biochemistry , smooth muscle , enzyme , cytosol

indicator Fura-2/AM. It was showed that endothelin and PDGF significantly induced a migration of vascular smooth muscle cells in a dosedependent manner, which was dose-dependently inhibited by pretreatment with 10-10mol/L sodium ferulate . The peak inhibition rate of migration induced by endothelin and PDGF were 85.04% and 81.92% (P 0.01) respectively. endothelin and PDGF provoked the rise of [Ca ]i in vascular smooth muscle cells, which was significantly suppressed by 10mol/L sodium ferulate (P 0.01). It is concluded that migration and rise of [Ca ]i induced by endothelin and PDGF in vascular smooth muscle cells from SHR may be suppressed by ferulate.

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