Effects of angiotensin II and insulin on ERK1/2 activation in fibroblasts from hypertensive patients*1 | Zendy

Michelangelo Sartori | Zendy

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Effects of angiotensin II and insulin on ERK1/2 activation in fibroblasts from hypertensive patients*1

Author(s) -

Michelangelo Sartori

Publication year - 2004

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2004.02.017

Subject(s) - medicine , angiotensin ii , endocrinology , insulin , insulin resistance , insulin receptor , renin–angiotensin system , kinase , mapk/erk pathway , angiotensin ii receptor type 1 , extracellular , receptor , blood pressure , biology , biochemistry

Insulin resistance, a frequent finding in hypertensive patients, leads to accelerated cardiovascular damage. It has been suggested that a crosstalk between angiotensin II and insulin signaling pathways may provoke insulin resistance, and may contribute to the development of cardiovascular damage. To identify a common pathophysiologic pathway between metabolic disorders and cardiovascular remodeling, we investigated the effect of angiotensin II and insulin on extracellular signal regulated kinases 1 and 2 (ERK1/2), isoforms of mitogen-activated protein kinases (MAPK) involved in cellular proliferation and extracellular matrix deposition.

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