No association of the Asp298 variant of the endothelial nitric oxide synthase gene with preeclampsia | Zendy

Ruth Landau | Zendy

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No association of the Asp298 variant of the endothelial nitric oxide synthase gene with preeclampsia

Author(s) -

Ruth Landau

Publication year - 2004

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2004.01.006

Subject(s) - preeclampsia , medicine , nitric oxide , enos , endothelial dysfunction , vasodilation , vasoconstriction , endothelium , nitric oxide synthase , endothelial nitric oxide synthase , endocrinology , population , pregnancy , cardiology , genetics , biology , environmental health

Preeclampsia, the most common serious complication of pregnancy, is characterized by vasoconstriction, dysfunction of the vascular endothelium, and hypertension. Unidentified genetic factors and impaired nitric oxide (NO)-mediated vasodilation are thought to contribute to the development of the syndrome. Polymorphisms of the endothelial nitric oxide synthase (eNOS) gene affect NO production and have been associated with hypertension and preeclampsia in a Japanese population.

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