Overexpression of Cu/Zn-superoxide dismutase and/or catalase in mice inhibits aorta smooth muscle cell proliferation | Zendy

Mingjian Shi | Zendy

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Overexpression of Cu/Zn-superoxide dismutase and/or catalase in mice inhibits aorta smooth muscle cell proliferation

Author(s) -

Mingjian Shi

Publication year - 2004

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2003.12.019

Subject(s) - catalase , superoxide dismutase , reactive oxygen species , vascular smooth muscle , hydrogen peroxide , cell growth , superoxide , protein kinase a , epidermal growth factor , medicine , dismutase , kinase , phosphorylation , microbiology and biotechnology , endocrinology , biochemistry , biology , oxidative stress , enzyme , smooth muscle , receptor

Increasing evidence demonstrates that reactive oxygen species, for example, superoxide (O(2)(-.)) and hydrogen peroxide (H(2)O(2)), promote vascular smooth muscle cell (VSMC) proliferation, and that superoxide dismutase (SOD) and catalase work in concert to scavenge O(2)(-.) and H(2)O(2). This report examined the effect of overexpressing Cu/Zn-SOD or catalase on epidermal growth factor (EGF)-induced proliferation and mitogen-activated protein kinase (MAPK) phosphorylation in VSMCs.

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