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There is limited evidence on the gene-environmental interaction among alpha-adducin G460W gene polymorphism, sodium intake, and blood pressure (BP) levels in a general population. One hypothesis is that the association between G460W polymorphism and BP is more evident among persons with higher sodium intake than those with lower sodium intake.

Alpha-adducin G460W polymorphism, urinary sodium excretion, and blood pressure in community-based samples