Mice lacking osteopontin exhibit increased left ventricular dilation and reduced fibrosis after aldosterone infusion | Zendy

Flora Sam | Zendy; Zhonglin Xie | Zendy; Henry Ooi | Zendy; David Kerstetter | Zendy; Wilson S. Colucci | Zendy; Mahipal Singh | Zendy; Krishna K. Singh | Zendy

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Mice lacking osteopontin exhibit increased left ventricular dilation and reduced fibrosis after aldosterone infusion

Author(s) -

Flora Sam,

Zhonglin Xie,

Henry Ooi,

David Kerstetter,

Wilson S. Colucci,

Mahipal Singh,

Krishna K. Singh

Publication year - 2004

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2003.10.007

Subject(s) - medicine , aldosterone , cardiology , osteopontin , fibrosis , dilation (metric space) , mineralocorticoid , endocrinology , mathematics , combinatorics

Osteopontin, also known as cytokine Eta-1, plays an important role in postmyocardial infarction remodeling by regulating collagen accumulation. Aldosterone promotes collagen synthesis and structural remodeling of the heart. The role of osteopontin in aldosterone-induced fibrosis and myocardial remodeling is unknown. Osteopontin expression and left ventricular structural and functional remodeling were determined in wild-type and osteopontin knockout mice after aldosterone infusion.

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