Plasma renin activity levels in hypertensive persons: their wide range and lack of suppression in diabetic and in most elderly patients | Zendy

Michael H. Alderman | Zendy

Open Access

Plasma renin activity levels in hypertensive persons: their wide range and lack of suppression in diabetic and in most elderly patients

Author(s) -

Michael H. Alderman

Publication year - 2003

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2003.08.015

Subject(s) - medicine , renin–angiotensin system , plasma renin activity , blood pressure , population , cardiology , endocrinology , environmental health

The renin-angiotensin system (RAS) maintains hemodynamic integrity by modulating both volume and vasoconstriction through a cybernetic feedback control mechanism. In addition, angiotensin II, the active component of the RAS, can be vasculotoxic and, in hypertensive individuals, is associated with increased cardiovascular morbidity and mortality. The objective of this study was to determine the distribution and determinants of plasma renin activity (PRA) in a representative sample of hypertensive persons.

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