Enhanced heme oxygenase-mediated coronary vasodilation in dahl salt-sensitive hypertension | Zendy

Robert A. Johnson | Zendy; Federico J. Teran | Zendy; William Durante | Zendy; Kelly J. Peyton | Zendy; Fruzsina K. Johnson | Zendy

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Enhanced heme oxygenase-mediated coronary vasodilation in dahl salt-sensitive hypertension

Author(s) -

Robert A. Johnson,

Federico J. Teran,

William Durante,

Kelly J. Peyton,

Fruzsina K. Johnson

Publication year - 2003

Publication title -

american journal of hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.009

H-Index - 136

eISSN - 1941-7225

pISSN - 0895-7061

DOI - 10.1016/j.amjhyper.2003.08.009

Subject(s) - medicine , contractility , heme oxygenase , vasodilation , cardioprotection , cardiology , endocrinology , perfusion , blood pressure , ventricular pressure , coronary circulation , heme , myocardial infarction , blood flow , chemistry , biochemistry , enzyme

Cardiovascular tissues express heme oxygenase (HO), which metabolizes heme to form carbon monoxide (CO). Carbon monoxide promotes relaxation of coronary vascular smooth muscle. Increased HO-1 expression provides cardioprotection during certain pathologic conditions. On a high salt (HS) diet Dahl salt-sensitive (DS) rats develop hypertension that is accompanied by left ventricular hypertrophy, whereas Dahl salt-resistant rats (DR) do not. This study tests the hypothesis that cardiac HO-1 expression is increased in DS rats with salt-induced hypertension and provides cardioprotection by promoting coronary vasodilation.

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