Aging and asthma – changes in CD45RA, CD29 and CD95 T cells subsets | Zendy

Ana TodoBom | Zendy; Anabela MotaPinto | Zendy; Vera Alves | Zendy; Manuel Santos-Rosa | Zendy

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Aging and asthma – changes in CD45RA, CD29 and CD95 T cells subsets

Author(s) -

Ana TodoBom,

Anabela MotaPinto,

Vera Alves,

Manuel Santos-Rosa

Publication year - 2011

Publication title -

allergologia et immunopathologia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 37

eISSN - 1578-1267

pISSN - 0301-0546

DOI - 10.1016/j.aller.2011.01.002

Subject(s) - medicine , asthma , immunology

Aging is associated with thymus involution leading to a reduction in naive T cells and to an accumulation of effector-memory cells. Apoptosis is a key mechanism to clear the immune system from activated and harmful cells. In asthma the stimulation of T cells by environmental antigens can decrease naive cells and sustain activated cells. The aim of this work was to evaluate the imbalance between CD45RA and CD29 cells during the aging process and their changes in elderly asthma and to evaluate how elderly and chronic diseases like asthma can affect susceptibility to apoptosis.

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