Significance of IgG4-positive cells in severe eosinophilic chronic rhinosinusitis | Zendy

Takahisa Koyama | Zendy; Shin Kariya | Zendy; Yasuharu Sato | Zendy; Yuka Gion | Zendy; Takaya Higaki | Zendy; Takenori Haruna | Zendy; Tazuko Fujiwara | Zendy; Akira Minoura | Zendy; Soshi Takao | Zendy; Yorihisa Orita | Zendy; Kengo Kanai | Zendy; Masami Taniguchi | Zendy; Kazunori Nishizaki | Zendy; Mitsuhiro Okano | Zendy

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Significance of IgG4-positive cells in severe eosinophilic chronic rhinosinusitis

Author(s) -

Takahisa Koyama,

Shin Kariya,

Yasuharu Sato,

Yuka Gion,

Takaya Higaki,

Takenori Haruna,

Tazuko Fujiwara,

Akira Minoura,

Soshi Takao,

Yorihisa Orita,

Kengo Kanai,

Masami Taniguchi,

Kazunori Nishizaki,

Mitsuhiro Okano

Publication year - 2018

Publication title -

allergology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.49

H-Index - 58

eISSN - 1440-1592

pISSN - 1323-8930

DOI - 10.1016/j.alit.2018.09.002

Subject(s) - medicine , eosinophilia , nasal polyps , eosinophilic , pathology , immunoglobulin e , immunohistochemistry , pathophysiology , chronic rhinosinusitis , biomarker , antibody , immunology , gastroenterology , biology , biochemistry

IgG4 production is regulated by type 2 (IL-4 and IL-13) and regulatory (IL-10) cytokines involved in the pathophysiology of chronic rhinosinusitis (CRS). We sought to determine the pathophysiological characteristics of IgG4-positive cells in sinonasal tissues in CRS, especially eosinophilic CRS (ECRS).

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