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The optimal age for epicutaneous sensitization following tape-stripping in BALB/c mice
Author(s) -
Masato Tamari,
Keisuke Orimo,
Kenichiro Motomura,
Ken Arae,
Akio Matsuda,
Susumu Nakae,
Hirohisa Saito,
Hideaki Morita,
Kenji Matsumoto
Publication year - 2018
Publication title -
allergology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.49
H-Index - 58
eISSN - 1440-1592
pISSN - 1323-8930
DOI - 10.1016/j.alit.2018.01.003
Subject(s) - sensitization , immunology , immunoglobulin e , spleen , cytokine , medicine , splenocyte , titer , balb/c , flow cytometry , chemistry , immune system , antibody
Direct contact of food proteins with eczematous lesions is thought to be the main cause of epicutaneous sensitization. To further investigate the development and pathogenesis of food allergy in vivo, a good mouse model of epicutaneous sensitization is needed. However, a fundamental problem in that regard is that the optimal age for epicutaneous sensitization of mice is unknown. In this study, we attempted to elucidate that optimal age.

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