Th9 cells induce steroid-resistant bronchial hyperresponsiveness in mice | Zendy

Mayumi Saeki | Zendy; Osamu Kaminuma | Zendy; Tomoe Nishimura | Zendy; Noriko Kitamura | Zendy; Akio Mori | Zendy; Takachika Hiroi | Zendy

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Th9 cells induce steroid-resistant bronchial hyperresponsiveness in mice

Author(s) -

Mayumi Saeki,

Osamu Kaminuma,

Tomoe Nishimura,

Noriko Kitamura,

Akio Mori,

Takachika Hiroi

Publication year - 2017

Publication title -

allergology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.49

H-Index - 58

eISSN - 1440-1592

pISSN - 1323-8930

DOI - 10.1016/j.alit.2017.07.001

Subject(s) - ovalbumin , dexamethasone , methacholine , bronchial hyperresponsiveness , immunology , medicine , eosinophilia , antigen , cell , inflammation , glucocorticoid , bronchoalveolar lavage , endocrinology , biology , lung , respiratory disease , genetics

Reduced responsiveness to corticosteroid therapy is a major problem for patients with severe asthma. Although Th9 cells, along with Th2 cells, facilitate antigen-induced airway eosinophilia and bronchial hyperresponsiveness (BHR), the sensitivity of Th9 cell-mediated responses to steroid therapy remains unknown. In this study, we investigated the effect of dexamethasone (Dex) on antigen-induced airway inflammation in Th9 cell-transferred mice.

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