Elevated uric acid and adenosine triphosphate concentrations in bronchoalveolar lavage fluid of eosinophilic pneumonia | Zendy

Takehito Kobayashi | Zendy; Kazuyuki Nakagome | Zendy; Tōru Noguchi | Zendy; Kiyoko Kobayashi | Zendy; Yutaka Ueda | Zendy; Tomoyuki Soma | Zendy; Kenji Ikebuchi | Zendy; Hidetomo Nakamoto | Zendy; Makoto Nagata | Zendy

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Elevated uric acid and adenosine triphosphate concentrations in bronchoalveolar lavage fluid of eosinophilic pneumonia

Author(s) -

Takehito Kobayashi,

Kazuyuki Nakagome,

Tōru Noguchi,

Kiyoko Kobayashi,

Yutaka Ueda,

Tomoyuki Soma,

Kenji Ikebuchi,

Hidetomo Nakamoto,

Makoto Nagata

Publication year - 2017

Publication title -

allergology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.49

H-Index - 58

eISSN - 1440-1592

pISSN - 1323-8930

DOI - 10.1016/j.alit.2017.06.010

Subject(s) - bronchoalveolar lavage , eosinophil , eosinophilic pneumonia , adenosine triphosphate , uric acid , immunology , eosinophilia , medicine , inflammation , pathogenesis , asthma , chemistry , lung

Recent evidence has suggested that the innate immune response may play a role in the development of eosinophilic airway inflammation. We previously reported that uric acid (UA) and adenosine triphosphate (ATP), two important damage-associated molecular pattern molecules (DAMPs), activate eosinophil functions, suggesting that these molecules may be involved in the development of eosinophilic airway inflammation. The objective of this study was to measure the concentrations of DAMPs including UA and ATP in the bronchoalveolar lavage fluid (BALF) of patients with eosinophilic pneumonia (EP).

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