Efficacy of oral immunotherapy with a rice-based edible vaccine containing hypoallergenic Japanese cedar pollen allergens for treatment of established allergic conjunctivitis in mice | Zendy

Ken Fukuda | Zendy; Waka Ishida | Zendy; Yosuke Harada | Zendy; Yuhya Wakasa | Zendy; Hidenori Takagi | Zendy; Fumio Takaiwa | Zendy; Atsuki Fukushima | Zendy

Open Access

Efficacy of oral immunotherapy with a rice-based edible vaccine containing hypoallergenic Japanese cedar pollen allergens for treatment of established allergic conjunctivitis in mice

Author(s) -

Ken Fukuda,

Waka Ishida,

Yosuke Harada,

Yuhya Wakasa,

Hidenori Takagi,

Fumio Takaiwa,

Atsuki Fukushima

Publication year - 2017

Publication title -

allergology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.49

H-Index - 58

eISSN - 1440-1592

pISSN - 1323-8930

DOI - 10.1016/j.alit.2017.06.006

Subject(s) - hypoallergenic , medicine , allergic conjunctivitis , immunology , spleen , oral immunotherapy , allergy , immunotherapy , splenocyte , genetically modified rice , pollen , lymph , transgene , food allergy , immune system , allergen , biology , genetically modified crops , pathology , botany , biochemistry , gene

We have previously shown that prophylactic oral administration of transgenic rice seeds expressing hypoallergenic modified antigens suppressed the development of allergic conjunctivitis induced by Japanese cedar pollen. We have now investigated the efficacy of oral immunotherapy with such transgenic rice for established allergic conjunctivitis in mice.

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