UDP/P2Y6 receptor signaling regulates IgE-dependent degranulation in human basophils | Zendy

Manabu Nakano | Zendy; Koichi Ito | Zendy; Takeo Yuno | Zendy; Nobuyuki Soma | Zendy; Syun Aburakawa | Zendy; Kosuke Kasai | Zendy; Toshiya Nakamura | Zendy; Hideki Takami | Zendy

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UDP/P2Y6 receptor signaling regulates IgE-dependent degranulation in human basophils

Author(s) -

Manabu Nakano,

Koichi Ito,

Takeo Yuno,

Nobuyuki Soma,

Syun Aburakawa,

Kosuke Kasai,

Toshiya Nakamura,

Hideki Takami

Publication year - 2017

Publication title -

allergology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.49

H-Index - 58

eISSN - 1440-1592

pISSN - 1323-8930

DOI - 10.1016/j.alit.2017.02.014

Subject(s) - degranulation , autocrine signalling , purinergic receptor , receptor , immunoglobulin e , basophil , extracellular , purinergic signalling , microbiology and biotechnology , p2 receptor , intracellular , p2y receptor , chemistry , biology , biochemistry , immunology , antibody , adenosine receptor , agonist

P2Y purinergic receptors (P2YR) are G protein-coupled receptors that are stimulated by extracellular nucleotides. They mediate cellular effects by regulating cAMP production, protein kinase C activation, inositol trisphosphate generation, and Ca 2+ release from intracellular stores. The P2Y6 receptor of this family is selectively stimulated by UDP, and selectively inhibited by MRS2578. In the present study, we examined the effect of UDP/P2Y6 receptor signaling on IgE-dependent degranulation in human basophils.

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