Genetic association of the functional CDHR3 genotype with early-onset adult asthma in Japanese populations | Zendy

Jun Kanazawa | Zendy; Hironori Masuko | Zendy; Yohei Yatagai | Zendy; Tohru Sakamoto | Zendy; Hideyasu Yamada | Zendy; Yoshiko Kaneko | Zendy; Haruna Kitazawa | Zendy; Hiroaki Iijima | Zendy; Takashi Naito | Zendy; Takefumi Saito | Zendy; Emiko Noguchi | Zendy; Satoshi Konno | Zendy; Masaharu Nishimura | Zendy; Tomomitsu Hirota | Zendy; Mayumi Tamari | Zendy; Nobuyuki Hizawa | Zendy

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Genetic association of the functional CDHR3 genotype with early-onset adult asthma in Japanese populations

Author(s) -

Jun Kanazawa,

Hironori Masuko,

Yohei Yatagai,

Tohru Sakamoto,

Hideyasu Yamada,

Yoshiko Kaneko,

Haruna Kitazawa,

Hiroaki Iijima,

Takashi Naito,

Takefumi Saito,

Emiko Noguchi,

Satoshi Konno,

Masaharu Nishimura,

Tomomitsu Hirota,

Mayumi Tamari,

Nobuyuki Hizawa

Publication year - 2017

Publication title -

allergology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.49

H-Index - 58

eISSN - 1440-1592

pISSN - 1323-8930

DOI - 10.1016/j.alit.2017.02.012

Subject(s) - atopy , asthma , odds ratio , medicine , rhinovirus , genotype , allele , immunology , genetic predisposition , genetic association , single nucleotide polymorphism , snp , genome wide association study , disease , genetics , biology , gene , virus

Recent studies have demonstrated that a coding SNP (rs6967330, Cys529→Tyr) in cadherin-related family member 3 (CDHR3), which was previously associated with wheezing illness and hospitalizations in infancy, could support efficient human rhinovirus C (RV-C) entry and replication. Here, we sought to examine the genetic contribution of this variant to the development of adult asthma.

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