CREB regulates TNF-α-induced GM-CSF secretion via p38 MAPK in human lung fibroblasts | Zendy

Yasuhiko Koga | Zendy; Takeshi Hisada | Zendy; Tamotsu Ishizuka | Zendy; Mitsuyoshi Utsugi | Zendy; Akihiro Ono | Zendy; Masakiyo Yatomi | Zendy; Yosuke Kamide | Zendy; Haruka AokiSaito | Zendy; Hiroaki Tsurumaki | Zendy; Kunio Dobashi | Zendy; Masanobu Yamada | Zendy

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CREB regulates TNF-α-induced GM-CSF secretion via p38 MAPK in human lung fibroblasts

Author(s) -

Yasuhiko Koga,

Takeshi Hisada,

Tamotsu Ishizuka,

Mitsuyoshi Utsugi,

Akihiro Ono,

Masakiyo Yatomi,

Yosuke Kamide,

Haruka AokiSaito,

Hiroaki Tsurumaki,

Kunio Dobashi,

Masanobu Yamada

Publication year - 2016

Publication title -

allergology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.49

H-Index - 58

eISSN - 1440-1592

pISSN - 1323-8930

DOI - 10.1016/j.alit.2016.03.006

Subject(s) - creb , secretion , tumor necrosis factor alpha , biology , cytokine , mapk/erk pathway , endocrinology , medicine , signal transduction , transcription factor , microbiology and biotechnology , immunology , biochemistry , gene

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that mediates eosinophilic differentiation, migration and survival, causing respiratory tract inflammation. GM-CSF is also known to be secreted from respiratory tract structural cells. However, the mechanisms of GM-CSF secretion have not been well established.

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