Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts | Zendy

Kengo Kanai | Zendy; Mitsuhiro Okano | Zendy; Tazuko Fujiwara | Zendy; Shin Kariya | Zendy; Takenori Haruna | Zendy; Ryotaro Omichi | Zendy; Seiichiro Makihara | Zendy; Yuji Hirata | Zendy; Kazunori Nishizaki | Zendy

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Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts

Author(s) -

Kengo Kanai,

Mitsuhiro Okano,

Tazuko Fujiwara,

Shin Kariya,

Takenori Haruna,

Ryotaro Omichi,

Seiichiro Makihara,

Yuji Hirata,

Kazunori Nishizaki

Publication year - 2016

Publication title -

allergology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.49

H-Index - 58

eISSN - 1440-1592

pISSN - 1323-8930

DOI - 10.1016/j.alit.2016.03.003

Subject(s) - prostaglandin d2 , receptor , vascular endothelial growth factor , nasal polyps , pathogenesis , prostaglandin , agonist , endocrinology , chemistry , medicine , biology , vegf receptors

Vascular endothelial growth factor (VEGF) is known to be associated with the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). VEGF is produced by a variety of cells including fibroblasts. It was recently reported that prostaglandin (PG) E 2 induces VEGF release by nasal polyp fibroblasts. However, little is known regarding possible regulation of VEGF by other PGs. We have reported that molecules that regulate PGD 2 metabolism play roles in the pathogenesis of CRS including in local eosinophilia and type 2 cytokine production. In the present study, we sought to determine whether PGD 2 regulates VEGF release by nasal polyp fibroblasts.

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