Hypereosinophilia with rash to dobutamine infusion; sulfite hypersensitivity diagnosed by in vitro stimulation assays | Zendy

Sung-Yoon Kang | Zendy; Ji-Won Lee | Zendy; Da-Eun Park | Zendy; Bo-ram Bae | Zendy; Hyun Seung Lee | Zendy; Byung-Keun Kim | Zendy; JuYoung Kim | Zendy; Kyung-Hwan Lim | Zendy; HeungWoo Park | Zendy; BonKwon Koo | Zendy; SangHeon Cho | Zendy; WooJung Song | Zendy

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Hypereosinophilia with rash to dobutamine infusion; sulfite hypersensitivity diagnosed by in vitro stimulation assays

Author(s) -

Sung-Yoon Kang,

Ji-Won Lee,

Da-Eun Park,

Bo-ram Bae,

Hyun Seung Lee,

Byung-Keun Kim,

JuYoung Kim,

Kyung-Hwan Lim,

HeungWoo Park,

BonKwon Koo,

SangHeon Cho,

WooJung Song

Publication year - 2016

Publication title -

allergology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.49

H-Index - 58

eISSN - 1440-1592

pISSN - 1323-8930

DOI - 10.1016/j.alit.2016.01.008

Subject(s) - hypereosinophilia , medicine , stimulation , rash , dobutamine , in vitro , immunology , pharmacology , dermatology , chemistry , eosinophilia , biochemistry , hemodynamics

Dobutamine is a widely prescribed form of inotropic support for patients with heart failure, but infusion thereof has been associated with hypersensitivity reactions, namely eosinophilia or eosinophilic myocarditis.1e5 However, it remains unclear whether the true culprit is dobutamine per se or its excipient, sulfite.6,7 We report a case of recurrent hypereosinophilia with a skin rash that developed during dobutamine infusion. We used an in vitro flow cytometric assay to show that the hypersensitivity was attributable to sulfite.

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