Eosinophil chemotaxis assay in nasal polyps by using a novel optical device EZ-TAXIScan: Role of CC-chemokine receptor 3 | Zendy

Hidekazu Saito | Zendy; Kohei Honda | Zendy; Chikara Asaka | Zendy; Shigeharu Ueki | Zendy; Kazuo Ishikawa | Zendy

Open Access

Eosinophil chemotaxis assay in nasal polyps by using a novel optical device EZ-TAXIScan: Role of CC-chemokine receptor 3

Author(s) -

Hidekazu Saito,

Kohei Honda,

Chikara Asaka,

Shigeharu Ueki,

Kazuo Ishikawa

Publication year - 2016

Publication title -

allergology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.49

H-Index - 58

eISSN - 1440-1592

pISSN - 1323-8930

DOI - 10.1016/j.alit.2016.01.001

Subject(s) - chemotaxis , eosinophil , eotaxin , ccr3 , eosinophil cationic protein , immunology , nasal polyps , chemokine , chemotaxis assay , cc chemokine receptors , chemokine receptor , receptor , medicine , biology , inflammation , asthma

The chemokine receptor, CC-chemokine receptor 3 (CCR3), and its major ligands, eotaxin, RANTES, and MCP-4, are involved in eosinophil chemotaxis. It is thought that CCR3 plays an important role in the recruitment and activation of eosinophils in nasal polyposis. We examined nasal polyp extract-induced eosinophil chemotaxis and the effect of a CCR3 antagonist using EZ-TAXIScan, a novel real-time chemotaxis assay device.

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