Effect of intranasal corticosteroid on pre-onset activation of eosinophils and mast cells in experimental Japanese cedar pollinosis | Zendy

Yasuyuki Noyama | Zendy; Mitsuhiro Okano | Zendy; Tazuko Fujiwara | Zendy; Shin Kariya | Zendy; Sei ichiro Makihara | Zendy; Takenori Haruna | Zendy; Kengo Kanai | Zendy; Takaya Higaki | Zendy; Kazunori Nishizaki | Zendy

Open Access

Effect of intranasal corticosteroid on pre-onset activation of eosinophils and mast cells in experimental Japanese cedar pollinosis

Author(s) -

Yasuyuki Noyama,

Mitsuhiro Okano,

Tazuko Fujiwara,

Shin Kariya,

Sei ichiro Makihara,

Takenori Haruna,

Kengo Kanai,

Takaya Higaki,

Kazunori Nishizaki

Publication year - 2016

Publication title -

allergology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.49

H-Index - 58

eISSN - 1440-1592

pISSN - 1323-8930

DOI - 10.1016/j.alit.2015.12.007

Subject(s) - provocation test , tryptase , nasal provocation test , medicine , fluticasone propionate , eosinophil cationic protein , fluticasone , nasal administration , placebo , allergy , eosinophil , corticosteroid , nasal spray , nasal lavage , immunology , asymptomatic , anesthesia , mast cell , allergen , asthma , pathology , alternative medicine

Minimal persistent inflammation (MPI) contributes to hyperreactivity in allergic rhinitis. However, little is known regarding whether pre-onset activation of eosinophils and mast cells is present or not in Japanese cedar pollinosis (JCP). Furthermore, a prophylactic effect of intranasal corticosteroids on such MPI in JCP has not been investigated.

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