Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN-γ production in chronic rhinosinusitis with nasal polyps | Zendy

Mitsuhiro Okano | Zendy; Tazuko Fujiwara | Zendy; Shin Kariya | Zendy; Takaya Higaki | Zendy; Seiichiro Makihara | Zendy; Takenori Haruna | Zendy; Yasuyuki Noyama | Zendy; Takahisa Koyama | Zendy; Ryotaro Omichi | Zendy; Yorihisa Orita | Zendy; K. Miki | Zendy; Kengo Kanai | Zendy; Kazunori Nishizaki | Zendy

Open Access

Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN-γ production in chronic rhinosinusitis with nasal polyps

Author(s) -

Mitsuhiro Okano,

Tazuko Fujiwara,

Shin Kariya,

Takaya Higaki,

Seiichiro Makihara,

Takenori Haruna,

Yasuyuki Noyama,

Takahisa Koyama,

Ryotaro Omichi,

Yorihisa Orita,

K. Miki,

Kengo Kanai,

Kazunori Nishizaki

Publication year - 2015

Publication title -

allergology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.49

H-Index - 58

eISSN - 1440-1592

pISSN - 1323-8930

DOI - 10.1016/j.alit.2015.08.005

Subject(s) - tlr3 , cytokine , toll like receptor , interleukin , immunology , chemistry , microbiology and biotechnology , medicine , biology , immune system , innate immune system

Toll-like receptor 3 (TLR3) is expressed in upper airways, however, little is known regarding whether Toll-like receptor 3 (TLR3) signals exert a regulatory effect on the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP), especially on eosinophilic inflammation. We sought to investigate the effect of Poly(IC), the ligand for TLR3, on cytokine production by dispersed nasal polyp cells (DNPCs).

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