Effect of beta2-adrenergic agonists on eosinophil adhesion, superoxide anion generation, and degranulation | Zendy

Tōru Noguchi | Zendy; Kazuyuki Nakagome | Zendy; Takehito Kobayashi | Zendy; Yutaka Ueda | Zendy; Tomoyuki Soma | Zendy; Hidetomo Nakamoto | Zendy; Makoto Nagata | Zendy

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Effect of beta2-adrenergic agonists on eosinophil adhesion, superoxide anion generation, and degranulation

Author(s) -

Tōru Noguchi,

Kazuyuki Nakagome,

Takehito Kobayashi,

Yutaka Ueda,

Tomoyuki Soma,

Hidetomo Nakamoto,

Makoto Nagata

Publication year - 2015

Publication title -

allergology international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.49

H-Index - 58

eISSN - 1440-1592

pISSN - 1323-8930

DOI - 10.1016/j.alit.2015.05.009

Subject(s) - superoxide , degranulation , chemistry , eosinophil , immunology , biochemistry , medicine , receptor , enzyme , asthma

Eosinophils play important roles in the development of asthma exacerbation. Viral infection is a major cause of asthma exacerbation, and the expression of IFN-γ-inducible protein of 10 kDa (IP-10) and cysteinyl leukotrienes (cysLTs) is up-regulated in virus-induced asthma. As β2-adrenergic agonists, such as formoterol or salbutamol, are used to treat asthma exacerbation, we examined whether formoterol or salbutamol could modify eosinophil functions such as adhesiveness, particularly those activated by cysLTs or IP-10.

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