Development of a novel electrospun nanofibrous delivery system for poorly water-soluble β-sitosterol | Zendy

Urve Paaver | Zendy; Ivo Laidmäe | Zendy; Hélder A. Santos | Zendy; Jouko Yliruusi | Zendy; Jaan Aruväli | Zendy; Karin Kogermann | Zendy; Jyrki Heinämäki | Zendy

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Development of a novel electrospun nanofibrous delivery system for poorly water-soluble β-sitosterol

Author(s) -

Urve Paaver,

Ivo Laidmäe,

Hélder A. Santos,

Jouko Yliruusi,

Jaan Aruväli,

Karin Kogermann,

Jyrki Heinämäki

Publication year - 2016

Publication title -

asian journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.021

H-Index - 39

eISSN - 2221-285X

pISSN - 1818-0876

DOI - 10.1016/j.ajps.2016.04.005

Subject(s) - nanofiber , electrospinning , dissolution , chemical engineering , sterol , materials science , polymer , water soluble , amorphous solid , recrystallization (geology) , chemistry , nanotechnology , cholesterol , organic chemistry , composite material , biochemistry , paleontology , engineering , biology

Electrospinning was used as a novel technique for fabricating polymeric nanofibers of a serum cholesterol lowering and poorly water-soluble plant sterol, β-sitosterol. Chitosan was used as a stabilizer/carrier polymer. The mean diameters of nanofibers ranged from 150 nm to 218 nm. β-sitosterol was in an amorphous form and homogeneously dispersed in the nanofibers. The β-sitosterol-loaded nanofibers were freely water-soluble and exhibited very short lag-time in releasing the plant sterol. The dissolution was associated with an immediate recrystallization of β-sitosterol in submicron level. In conclusion, electrospinning is a promising future technology for the formulation of poorly water-soluble plant sterols

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