Open AccessThe relationship between plasma viral load and neuropsychological functioning in HIV-1 infection
Author(s) -
Mihály Réger,
D. Martin,
S COLE,
Gregory P. Strauss
Publication year - 2004
Publication title -
archives of clinical neuropsychology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 98
eISSN - 1873-5843
pISSN - 0887-6177
DOI - 10.1016/j.acn.2004.03.009
Subject(s) - viral load , neuropsychology , viral encephalitis , neuropsychological test , cognition , medicine , neuropsychological testing , neuropsychological assessment , clinical psychology , cognitive skill , human immunodeficiency virus (hiv) , psychology , immunology , encephalitis , psychiatry , virus
Plasma viral load is helpful in monitoring systemic HIV infection but the relationship between plasma viral load and CNS functioning remains unclear. Equivocal results have been reported on the relationship between plasma viral load and cognitive functioning. The present study tested cognitive functions with a standardized neuropsychological battery consisting of 28 test scores. Participants (N=140) were grouped into undetectable (<400 copies), low (401-10,000 copies), or moderate (10,001-100,000 copies) viral load groups. Statistical analyses (MANOVA and MANCOVA) revealed no differences in neuropsychological test performance between the viral load groups. Fairly healthy patients with moderate plasma viral loads do not appear to show increased neuropsychological dysfunction. CSF viral load may be more helpful in evaluating cognitive correlates of HIV encephalitis.
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