Case for diagnosis. Dorsal nodule in a 10-year-old male | Zendy

Gongjun Xu | Zendy; Xuefeng Fu | Zendy; Jinxian Fang | Zendy; Chiqing Huang | Zendy

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Case for diagnosis. Dorsal nodule in a 10-year-old male

Author(s) -

Gongjun Xu,

Xuefeng Fu,

Jinxian Fang,

Chiqing Huang

Publication year - 2021

Publication title -

anais brasileiros de dermatologia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.461

H-Index - 44

eISSN - 1806-4841

pISSN - 0365-0596

DOI - 10.1016/j.abd.2020.08.009

Subject(s) - synaptophysin , cd68 , pathology , cytokeratin , immunohistochemistry , granular cell tumor , vimentin , nodule (geology) , biopsy , epithelioid cell , medicine , soft tissue , eosinophilic , biology , paleontology

Granular cell tumors (GCTs) are rare soft-tissue neoplasms. GCT immunohistochemistry is positive for S-100, NSE, and CD68. This report describes the case of a 10-year-old male who presented with a dorsal nodule. A biopsy revealed aggregates and sheets of large epithelioid and spindle cells. The cells had abundant eosinophilic granular cytoplasm. Immunohistochemical analysis was positive for CD68, NKI/C3, and synaptophysin; weakly positive for NSE; and negative for S-100, SOX10, HMB45, Melan A, cytokeratin, SMA, EMA, and CD163. The Ki-67 index was less than 1%. A diagnosis of an S-100 negative, cutaneous, benign GCT was determined.

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