Diffuse normolipemic plane xanthoma and hepatitis C: chance?

Diffuse Normolipemic Plane Xanthoma (DNPX) is a rare acquired dermatosis, clinically characterized by patches and/or yellow-orange plaques symmetrically distributed. It is an uncommon type of non-Langerhans histiocytosis that occurs due to the deposition of lipids in the skin and, in almost half of cases, occur in the absence of hypercholesterolemia. DNPX has been associated with systemic diseases such as multiple myeloma and other hematological and lymphoproliferative neoplasms. A case of diffuse normolipemic plane xanthoma with no lipid profile changes is reported in a patient with a recent diagnosis of Hepatitis C. A 61 year-old man with a history of onset of asymptomatic yellowish spots, 2 years ago, initially on the eyelids. In one year, the lesions also appeared in the armpits, in the inguinal, genital and gluteal regions. He had a recent diagnosis of Hepatitis C (HCV), without treatment. He denied other comorbidities and use of medications. On examination he had yellowish plaques with a symmetrical distribution in the periorbital region bilaterally (Fig. 1), and plaques with regular, well-delimited borders, yellow-orange in the