Allergic contact dermatitis to slime

Slime is the colloquial name of a viscoelastic product used as a toy that has gained popularity in recent years among children and adolescents worldwide. It may be home-made or industrialized. The former is obtained by mixing cosmetic and household products, including shaving foams, contact lens solutions containing boric acid, glues, liquid detergents and powdered soap, among others. We report the case of a 9-year-old girl, with personal history of atopy for 5 years with periods of exacerbation related to slime manipulation. The patient’s mother informed that she used to play with both: a commercial slime bought at a toy store, and also a home-made one, created by herself using body moisturizer, boricated water, glue, baking soda, blue food dye and shaving foam. Dermatological examination showed intense palmar erythema, with multiple vesicles associated with desquamation and some exulcerated areas (Fig. 1). Treatment was introduced with 0.5 mg/kg/day systemic corticosteroid therapy and, after 2 months, patch test was performed using the Brazilian standard series, and also complementary aqueous solution of methylisothiazolinone (0.02%) and a part of the industrialized slime (even knowing the possibility of false-positive reactions because of the potential irritants in its composition) (Fig. 2). The 96 h-reading showed positive results for Kathon CG 2 + (a mixture of methylisothiazolinone and methylchlorothiazolinone), and also for isolated methylisothiazolinone (MI) 2 + (Fig. 3), which is a component present in the specific moisturizer, glue and shaving foam used by the patient in manufacturing the homemade slime. The company responsible for manufacturing the industrialized slime was contacted, and they informed that the only preservatives used in its composition were the parabens, which had negative results in the patch test. Slime can cause both Irritant (ICD) and Allergic Contact Dermatitis (ACD), especially when it is home-made, and so is prepared with the addition of different commercial products. When irritant, boric acid, alcohols and glycol compounds are responsible for the aggression of the skin barrier. On the other hand, allergens such as methylisothiazolinone and methylchlorothiazolinone are well recognized as causing ACD, and are used as preservatives in industrialized and cosmetic products, such as moist wipes, moisturizers, makeup cleaners glues, among others. In the present case, this preservative was present in the body moisturizer, the shaving foam and the glue used by the patient, revealing the importance of identifying the allergens in the numerous products that may be used. Atopic patients are prone to the development of ACD due to deficiency of the skin barrier and also to frequent use of