Successful therapeutic approach in a patient with elephantiasic pretibial myxedema | Zendy

Marina Ferreira | Zendy; Luciana Helena Zacaron | Zendy; Annair Freitas do Valle | Zendy; Aloísio Gamonal | Zendy

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Successful therapeutic approach in a patient with elephantiasic pretibial myxedema

Author(s) -

Marina Ferreira,

Luciana Helena Zacaron,

Annair Freitas do Valle,

Aloísio Gamonal

Publication year - 2019

Publication title -

anais brasileiros de dermatologia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.461

H-Index - 44

eISSN - 1806-4841

pISSN - 0365-0596

DOI - 10.1016/j.abd.2019.02.007

Subject(s) - medicine , myxedema , therapeutic modalities , dermatology , hyaluronic acid , treatment modality , graves' disease , thyroid , glycosaminoglycan , pathology , disease , surgery , anatomy

Localized pretibial myxedema is a dermopathy whose treatment is a challenge in dermatology, occurring in 0.5-4% of patients with Graves' disease. This autoimmune thyroid condition stimulates the production of hyaluronic acid and glycosaminoglycans that are deposited particularly in the pretibial region. Clinically, it presents as a localized, circumscribed, and non-depressible infiltrate in plaques. Several treatment modalities have been proposed, and their results vary, with worse response observed in severe cases. This report presents the case of a patient with elephantiasic pretibial myxedema who was subjected to intralesional corticosteroid applications, resulting in an excellent and encouraging therapeutic response that was maintained.

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