Open AccessHigh-resolution ion isolation with the ion cyclotron resonance capacitively coupled open cell
Author(s) -
Peter B. O’Connor,
Fred W. McLafferty
Publication year - 1995
Publication title -
journal of the american society for mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.961
H-Index - 127
eISSN - 1879-1123
pISSN - 1044-0305
DOI - 10.1016/1044-0305(95)00232-3
Subject(s) - chemistry , fourier transform ion cyclotron resonance , ion cyclotron resonance , ion , analytical chemistry (journal) , excitation , atomic physics , nuclear magnetic resonance , cyclotron , physics , organic chemistry , chromatography , quantum mechanics
For ion cyclotron resonance, a capacitively coupled open cell variant with fourfold radial symmetry was constructed and tested for axial excitation-ejection of large ions at high resolution. With a reverse of frequency sweep direction, this cell gave substantial improvements in signal-to-noise ratio due to linearization of the excitation electric field. Single isotopic peaks of ubiquitin (8.6-kDa) and carbonic anhydrase (29-kDa) molecular ions could be isolated by selective stored waveform inverse Fourier transform excitation, which yielded an order of magnitude higher isolation resolving power than previously achieved at high mass-to-charge ratio values.