Open AccessCounting single cells and computing their heterogeneity: from phenotypic frequencies to mean value of a quantitative biomarker
Author(s) -
Qian Hong,
Cheng YuChen
Publication year - 2020
Publication title -
quantitative biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.707
H-Index - 15
eISSN - 2095-4697
pISSN - 2095-4689
DOI - 10.1007/s40484-020-0196-3
Subject(s) - statistics , biomarker , phenotype , sample size determination , sample (material) , population , value (mathematics) , expected value , probability distribution , mathematics , statistical physics , biology , physics , genetics , medicine , thermodynamics , environmental health , gene
This tutorial presents a mathematical theory that relates the probability of sample frequencies, of M phenotypes in an isogenic population of N cells, to the probability distribution of the sample mean of a quantitative biomarker, when the N is very large. An analogue to the statistical mechanics of canonical ensemble is discussed.