Histamine H4 receptor signalling in tongue cancer and its potential role in oral carcinogenesis - a short report | Zendy

Abdelhakim Salem | Zendy; Rabeia Almahmoudi | Zendy; Dyah Listyarifah | Zendy; Maria Siponen | Zendy; Katariina Maaninka | Zendy; Ahmed AlSamadi | Zendy; Tuula Salo | Zendy; Kari K. Eklund | Zendy

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Histamine H4 receptor signalling in tongue cancer and its potential role in oral carcinogenesis - a short report

Author(s) -

Abdelhakim Salem,

Rabeia Almahmoudi,

Dyah Listyarifah,

Maria Siponen,

Katariina Maaninka,

Ahmed AlSamadi,

Tuula Salo,

Kari K. Eklund

Publication year - 2017

Publication title -

cellular oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.698

H-Index - 40

eISSN - 2211-3436

pISSN - 2211-3428

DOI - 10.1007/s13402-017-0336-6

Subject(s) - carcinogenesis , histamine , mast cell , cancer research , histamine h4 receptor , biology , immunostaining , cancer , pathology , oncogene , oral mucosa , immunology , medicine , receptor , immunohistochemistry , histamine h2 receptor , cell cycle , antagonist

Recent reports indicate that histamine and its novel, high-affinity histamine H 4 receptor (H 4 R) play a role in carcinogenesis, and thus H 4 R signalling has become a focus of increasing interest in the pathogenesis of many cancers. The roles of H 4 R in oral epithelial dysplasia (OED) and oral tongue squamous cell carcinoma (OTSCC) are unknown. The purpose of this study was to assess H 4 R expression in OTSCC patients and in OTSCC-derived cell lines.

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